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Combined Amoxicillin for Intramammary Administration (For Lactating Period)
Product Name: Combined Amoxicillin for Intramammary Administration (For Lactating Period)
Main Ingredients
Amoxicillin trihydrate, sodium succinate, and prednisolone.
Appearance
A white to nearly white oily suspension.
Pharmacological Action
Pharmacodynamics: Amoxicillin is a broad-spectrum β-lactam antibiotic that exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. It is effective against various gram-positive and gram-negative bacteria causing mastitis, such as staphylococci, streptococci, and Escherichia coli. Succinate is an irreversible competitive β-lactamase inhibitor, capable of inhibiting β-lactamases of types II, I, I, and V, thereby protecting β-lactam antibiotics and enhancing their antibacterial effect. Prednisolone provides anti-inflammatory effects, helping to reduce tissue inflammation and edema, thus promoting the recovery of mammary glands.
Pharmacokinetics: After three repeated administrations, the maximum concentration of amoxicillin in milk is reached at 3.33 hours (352.75 μg/mL); prednisolone at 2.5 hours (26.20 μg/mL); and succinate at 2.33 hours (134.68 μg/mL). Following intramammary administration, amoxicillin, prednisolone, and succinate are excreted with the milk during milking.
Indications
Used for the treatment of mastitis in lactating cows caused by susceptible gram-positive and gram-negative bacteria.
Dosage and Administration
Intramammary administration: after milking, inject 3 g into each affected quarter, every 12 hours, for a total of 3 injections.
Adverse Reactions
Very rare allergic reactions to amoxicillin may occur.
Important Notes
For use in cows only. Milk from treated animals must not be used for human consumption.
Residue levels of succinate in milk have not been fully studied; potential risk should be considered.
Avoid contact if allergic to penicillins.
Users should take precautions to avoid direct contact with the product.
Keep out of reach of children.
Withdrawal Period
60 hours.
Specification
3 g: 0.2 g (as C₁₆H₁₉N₃O₅S) + 0.05 g (as C₈H₁₁NO₅S) + 0.01 g (as C₂₁H₂₈O₅)
Packaging
3 g/tube × 24 tubes/box
Storage
Store below 25°C, in a sealed container (single-use syringe).
Manufacturer and Packer
Eastern Along Pharmaceutical Co., Ltd
Address: Room 3A-9, 12 / F, Kai Ching Centre, 18 Cheung Street, Sai Ying Pun, Hong Kong
E-mali：hujiahao@ramical.com
